To combat overfishing in the wild, fish farming is a practice that dates back thousands of years. Aquaculture has proliferated in response to rising demand and declining world fish stocks due to overfishing. The majority of aquaculture comes from Asia, with the Chinese responsible for about 60% of its output. Similarly, when agriculture attempts to meet consumer demand, fish farming faces many challenges. Densely packed fish pens can lead to the spread of disease, which is combatted by producers' antibiotic use. If fish escape their enclosures or conditions naturally spread, native populations are at risk. A U.S Government agency, The National Oceanic and Atmospheric Administration (NOAA) accounts that one pound of farmed salmon uses fish oil from five pounds of wild fish and fish meal from 1.3 pounds of fish. If aquaculture will remain at such a large scale, it is essential to ensure its practice is sustainable.